|
| | RSS Feeds | | | Subscribe for Newsletter | | |
|
|
Chemotherapy drug used to treat cancer has fatal allergic reaction |
|
|
Researchers have revealed that a chemotherapy drug used to treat cancer, results in fatal allergic reactions.
Researchers at Northwestern University Feinberg School of Medicine have identified 287 unique cases of hypersensitivity reactions submitted to the FDA`s Adverse Event Report System from 1997-2007, with 109 deaths in patients who received Cremophor-based paclitaxel, a solvent-administered taxane chemotherapy.
The researchers said as the adverse event reports generally only represent from 1% to 10% of actual incidence, so the number of hypersensitivity reactions and deaths is likely significantly higher.
Lead researcher Dr. Charles Bennett of Northwestern`s Feinberg School and Dennis Raisch of the University of New Mexico said that the severe allergic reactions are believed to be caused by Cremophor, the chemical solvent. It is a derivative of castor oil that is used to dissolve some insoluble drugs before they can be injected into the blood stream.
Two patients who died from an allergic reaction had early-stage breast cancer, which had been surgically removed, and were being treated with Cremophor-containing paclitaxel to prevent the cancer from coming back. Both of those patients had received medications before the chemotherapy to reduce the risk of hypersensitivity reactions.
Bennett said, "The deaths of women with early-stage breast cancer are particularly disturbing because without the adverse reaction, they could have likely had 40 years of life ahead of them."
(Posted on : 12/06/2009)
|
|
|
|
|
|
| Chemotherapy drug used to treat cancer has fatal allergic reaction |
|
